Wake, 17 bytes

":"Hello, World!"

According to the official website,

Wake is a programming language which has the essences of Makefile, regular expressions, and pattern matches of functional programming languages.

Wake was created by shinh and can be tested on his golf server Anarchy Golf.

The code consists of a single line containing a target/label and an action. Since the action is a string literal, it gets printed to STDOUT.

Using " for the target served two purposes:

• It provides polyglot protection.

  Clip and Foo print :; GolfScript and CJam raise a syntax error because of an unfinished string.

• It provides a little uncertainty about how the code is supposed to work.