As you can see in this answer, in many SQL engines you can use the IS DISTINCT FROM clause which will always return a True or False value.
More info: Most SQL engines use Three-valued logic. This means that a conditional can return True, False or, in case of comparison with a NULL value, Unknown.
So, as an example, in a table like
A query like
SELECT * FROM table WHERE col <> 1
would return
since 1 <> NULL doesn't return True but Unknown.
Instead, a query like
SELECT * FROM table WHERE col IS DISTINCT FROM 1
would return
since 1 IS DISTINCT FROM NULL returns True.