You can turn a grid on/off with grid(), but it's only possible to have the grid lines on axis ticks, so if you want it hand-made, what about this:
import numpy as np
import matplotlib.pyplot as plt
from matplotlib.patches import Rectangle
xs = np.linspace(0, 100, 51)
ys = np.linspace(0, 10, 21)
ax = plt.gca()
# grid "shades" (boxes)
w, h = xs[1] - xs[0], ys[1] - ys[0]
for i, x in enumerate(xs[:-1]):
for j, y in enumerate(ys[:-1]):
if i % 2 == j % 2: # racing flag style
ax.add_patch(Rectangle((x, y), w, h, fill=True, color='#008610', alpha=.1))
# grid lines
for x in xs:
plt.plot([x, x], [ys[0], ys[-1]], color='black', alpha=.33, linestyle=':')
for y in ys:
plt.plot([xs[0], xs[-1]], [y, y], color='black', alpha=.33, linestyle=':')
plt.show()
