Filter the non-null get the value of last one, if you need the index get the index from the value. But requires the values to be unique.
// Last non-null value
const lastNonNull = arr.filter(x => x).pop();
// Index of last non-null
const indexOfLastNonNull = arr.indexOf(lastNonNull);
--Edit(1)
You may want to use reduce method of arrays, but before run reverse to make sure the sequence is from last to first.
reduce works pretty fine, the first initial value is null then we check for result which is the first initial value so we pass on cur which is the first element of array, if it is truthy we return idx which is the index of array, if not we return null which will become the result in the next loop.
arr.reduce((result, cur, idx) => (result ? result : (cur ? idx : null)), null)
--Edit(2)
Or you may reverse the array and run indexOf like this:
arr.indexOf(null);
For reversing once you run arr.reverse() it'll reverse the content of array. No need to return anything.