@prisma/client did not initalize

I see that you are trying to define Prisma outside the context, there is nothing wrong with your approach, although there are reason as to why you should not do that.

Defining Prisma outside the context in Hono (or any framework) is discouraged because it can lead to connection pooling issues, especially in serverless environments. If Prisma is defined globally, it may hold onto stale connections, leading to failed queries or exhausted connection pools. By defining it inside the request context, you ensure fresh connections for each request. In traditional long-running servers, defining Prisma globally can work, but it's not ideal for serverless setups.

Found this article that can help you understand more: Is better pass prisma object through context to resolvers or use it directly?

Also here is a snippet as to how you should use Prisma:

export const getAllUsers = async (c: Context) => {
  const prisma = new PrismaClient({
    datasourceUrl: c.env.DATABASE_URL,
  }).$extends(withAccelerate());

  try {
    const res = await prisma.user.findMany();
    return c.json({
      users: res.map((user) => ({
        id: user.id,
        username: user.username,
        email: user.email,
      })),
    });
  } catch (error) {
    return c.body(`Internal server error: ${error}`, 500);
  }
};