You can do this in many ways depending on what you're trying to achieve.
You can easily do this by adding uniqueness to the url for the iframe.
Ex. if you're setting the iframe using javascript you can set the src to
var date = new Date();
iframe.src = 'http://www.phy.mtu.edu/basiccomputing/sample.html?datetime=' + date.getTime();
If you have control over the sample.html page you can set
<META HTTP-EQUIV="CACHE-CONTROL" CONTENT="NO-CACHE">
You can also set the cache-control, last-modified and etag headers to make the browser revalidate the page every time but this is a bit tricky to do... or at least get to work across all browsers :).