You are going to have to use Worksheet_Calculate. It's unclear on whether the 'streaming' will trigger a Worksheet_Calculate in Sheet2 but the linked cell in Sheet1 will definitely trigger a Worksheet_Calculate in that worksheet's private code sheet providing you have calculation set to automatic.
You need a variable that will hold previous values of Sheet1!A1 that can be compared to the current value of Sheet1!A1. Some prefer to use a public var declared in a public module's declaration area; I prefer to use a static var within Sheet1's Worksheet_Calculate itself.
From Microsoft Docs,
Normally, a local variable in a procedure ceases to exist as soon as the procedure stops. A static variable continues to exist and retains its most recent value. The next time your code calls the procedure, the variable is not reinitialized, and it still holds the latest value that you assigned to it. A static variable continues to exist for the lifetime of the class or module that it is defined in.
The first issue is seeding the static variable for its first use. A variant-type variable that has never been given a value report True when tested with IsEmpty so when the workbook is first opened, the first calculation cycle will simply record the value of Sheet1!A1 into the static var. Any future calculation cycle will compare the value in Sheet1!A1 to the value held in the static var and if they are different, the external sub procedure ('... run a macro ...' according to your question's narrative) will be run and the new value of Sheet1!A1 will be stored in the static var. In this way, any change in the value returned by the formula in Sheet1!A1 will force a calculation cycle, hence the worksheet's Worksheet_Calculate event sub procedure which will in turn run your external sub procedure.
In Sheet1's private code sheet
Option Explicit
Private Sub Worksheet_Calculate()
Static s2d10 As Variant
If IsEmpty(s2d10) Then
'load static var with expected value
s2d10 = Cells(1, "A").Value2
ElseIf s2d10 <> Cells(1, "A").Value2 Then
'run sub procedure here
'... run a macro ...'
'load A1's current value into the static var
s2d10 = Cells(1, "A").Value2
End If
End Sub