The define function is for "defining" modules with dependencies using AMD style, and require is mostly used to call those modules previously defined with define function.
The recommended practice is to define only one module per file, but you can add more than one define if you pass the name of the module as the first argument to that function.
If you pass the name explicitly to the define function you can nest define inside a require call, but it will make no sense, because all the dependencies passed to the require can be passed to the define directly, which is faster an clearer than nesting defines inside requires.
Maybe, nesting a require inside a define could be more useful, perhaps if you have a module with dependencies that are only required under certain conditions, it could make sense to add the common dependencies on the define function, and the more specific ones with a require inside a conditional statement.
In my opinion the important concept is to understand that basically define is for defining AMD modules, and require is for calling them. (you can use non AMD files as dependencies but this is other matter.)
defineexplicitly.defineis normally executed as a result of arequirecall for that module. So you wouldrequire(["foo/title"])from within your code, and that would cause the module to be loaded/defined.