You could do this with some awk scripting. Here is a piece of code I came up with to address your problem :
awk 'BEGIN {col=3; sep=" "; forbidden=sep} {if (match(forbidden, sep $col sep) == 0) {forbidden=forbidden $col sep; print $0}}' input.file
The BEGIN keyword declares the forbidden string, which is used to monitor the 3rd column values. Then, the match keyword check if the 3rd column of the current line contains any forbidden value. If not, it adds the content of the column to the forbidden list and print the whole line.
Here, sep=" " instantiate the separator. We use sep between each forbidden value in order to avoid words created by putting several values next to one another. For instance :
1 1111 ta
2 2222 to
3 3333 t
4 4444 tato
In this case, without a separator, t and tato would be considered a forbidden value. We use " " as a separator as it is used by default to separate each column, thus a column cannot include a space in its name.
Note that if you want to change the number of the column in which you need to remove duplicate, just adapt col=3 with the number of the column you need (0 for the whole line, 1 for the first column, 2 for the second, ...)