I've managed this using node-http-proxy, where http://first.test/ and http://second.test/ are the hostnames.
var http = require('http'),
httpProxy = require('http-proxy');
var proxy = httpProxy.createProxyServer({});
// reverse proxy server
http.createServer(function (req, res) {
var target = '';
if (req.headers.host.match(/first.test/)) {
target = 'http://127.0.0.1:8001';
} else if (req.headers.host.match(/second.test/)) {
target = 'http://127.0.0.1:8002';
}
console.log(req.headers.host, '->', target);
proxy.web(req, res, { target: target });
}).listen(8000);
// test server 1
http.createServer(function(req, res) {
res.writeHead(200, { 'Content-Type': 'text/plain' });
res.write('8001\n');
res.write(JSON.stringify(req.headers, true, 2));
res.end();
}).listen(8001);
// test server 2
http.createServer(function(req, res) {
res.writeHead(200, { 'Content-Type': 'text/plain' });
res.write('8002\n');
res.write(JSON.stringify(req.headers, true, 2));
res.end();
}).listen(8002);