In [201]: df = pd.DataFrame(np.random.randn(10, 4))
In [202]: df
Out[202]:
0 1 2 3
0 -1.380064 0.391358 -0.043390 -1.970113
1 -0.612594 -0.890354 -0.349894 -0.848067
2 1.178626 1.798316 0.691760 0.736255
3 -0.909491 0.429237 0.766065 -0.605075
4 -1.214366 1.907580 -0.583695 0.192488
5 -0.283786 -1.315771 0.046579 -0.777228
6 1.195634 -0.259040 -0.432147 1.196420
7 -2.346814 1.251494 0.261687 0.400886
8 0.845000 0.536683 -2.628224 -0.238449
9 0.246398 -0.548448 -0.295481 0.076117
In [203]: df.iloc[:, (df.iloc[-1] > 0).values]
Out[203]:
0 3
0 -1.380064 -1.970113
1 -0.612594 -0.848067
2 1.178626 0.736255
3 -0.909491 -0.605075
4 -1.214366 0.192488
5 -0.283786 -0.777228
6 1.195634 1.196420
7 -2.346814 0.400886
8 0.845000 -0.238449
9 0.246398 0.076117
Basically this solution uses very basic Pandas indexing, in particular iloc() method