There is no such thing as a request status code. Only the response, sent back from the server to the client, has an HTTP status code.
The closest you can do is setting a Custom Error Responses via an ErrorDocument directive. This means, based on some status code e.g. 404, you can call some server side script, which acts appropriately.
ErrorDocument 404 /var/www/html/errors/handle_404.php
This works for status codes starting with 400 and 500, but not for response codes in the range of 200 or 300. See again Custom Error Responses
Customized error responses can be defined for any HTTP status code designated as an error condition - that is, any 4xx or 5xx status.
Addressing comments, the syntax of ErrorDocument is defined as
Syntax: ErrorDocument error-code document
So there is just the error-code (4xx-5xx) to handle, and some document to show or execute, no way to define any additional flags.
200code if you're doing "pretty" urls, because the pretty url almost NEVER exists as an actual file on the server. so by definition all pretty urls themselves are 404s. Only what they get rewritten TO would be a 200.