JavaScript has both primitive strings and string objects. What you've written there is a primitive string. The Object.prototype.isPrototypeOf method always returns false for any primitive, so your results make sense.
If you used a string object, you'd get true:
var myStr = new String("Sample");
console.log(String.prototype.isPrototypeOf(myStr)); // true
console.log(Object.prototype.isPrototypeOf(myStr)); // true
You're probably wondering: If it's a primitive, then why can I call methods on it that are defined on String.prototype?
The answer is that the specification defines that if you use a property accessor on a primitive string, a temporary string object with an equivalent character sequence is created (with String.prototype as its prototype), and the property is then read from that temporary object. (The same is done with numbers.)
We can prove that the temporary object is created by adding a method to String.prototype that returns that object (just for the purposes of illustration):
Object.defineProperty(String.prototype, "foo", {
value: function() {
return this;
}
});
var primitive = "string";
var object = primitive.foo();
console.log(primitive === object); // false
console.log(primitive == object); // true
console.log(String.prototype.isPrototypeOf(primitive)); // false
console.log(String.prototype.isPrototypeOf(object)); // true