No. At least I never heard of such. Simple check does not give hope for it either:
t=# select setting, name from pg_settings where name like '%null%';
setting | name
---------+-----------------------
on | array_nulls
off | transform_null_equals
(2 rows)
https://www.postgresql.org/docs/current/static/queries-order.html does not mention such global switches either, just:
The NULLS FIRST and NULLS LAST options can be used to determine
whether nulls appear before or after non-null values in the sort
ordering. By default, null values sort as if larger than any non-null
value; that is, NULLS FIRST is the default for DESC order, and NULLS
LAST otherwise.
ORDER BY (column IS NULL), column DESC.falsecomes first inASCorder so by default nulls will be last. I don't know about configuration tho.