If you know the column names prior, you can do it by setting usecols parameter
When you know which columns to use
Suppose you have csv file with columns ["id", "name", "last_name"] and you want just ["name", "last_name"]. You can do it as below:
import pandas as pd
df = pd.read_csv("sample.csv", usecols=["name", "last_name"])
when you want first N columns
If you don't know the column names but you want first N columns from dataframe. You can do it by
import pandas as pd
df = pd.read_csv("sample.csv", usecols=[i for i in range(n)])
Edit
When you know name of the column to be dropped
# Read column names from file
cols = list(pd.read_csv("sample_data.csv", nrows=1))
print(cols)
# Use list comprehension to remove the unwanted column in **usecol**
df= pd.read_csv("sample_data.csv", usecols =[i for i in cols if i != "name"])