Based on the doc:AAD V2.0 end pointRestrictions on protocols ,The OAuth 2.0 Resource Owner Password Credentials Grant is not supported by the v2.0 endpoint.
In python ADAL sdk , client secret is not accepted by acquire_token_with_username_password method, so you need to register native app.
Sample code:
import adal
import requests
tenant = ""
client_id = "app id"
# client_secret = ""
username = ""
password = "”
authority = "https://login.microsoftonline.com/" + tenant
RESOURCE = "https://graph.microsoft.com"
context = adal.AuthenticationContext(authority)
# Use this for Client Credentials
#token = context.acquire_token_with_client_credentials(
# RESOURCE,
# client_id,
# client_secret
# )
# Use this for Resource Owner Password Credentials (ROPC)
token = context.acquire_token_with_username_password(RESOURCE, username, password, client_id)
graph_api_endpoint = 'https://graph.microsoft.com/v1.0{0}'
# /me only works with ROPC, for Client Credentials you'll need /<UsersObjectId/
request_url = graph_api_endpoint.format('/me')
headers = {
'User-Agent' : 'python_test',
'Authorization' : 'Bearer {0}'.format(token["accessToken"]),
'Accept' : 'application/json',
'Content-Type' : 'application/json'
}
response = requests.get(url = request_url, headers = headers)
print (response.content)
In addition, native app is not necessary if you use REST API, but client secret need to be set.

Hope it helps you.