Execute an Uninstall-Setup from server on remote computers via PowerShell

You can try the following approach.

Note that the need to provide credentials explicitly is a workaround for the infamous double-hop problem.

# The list of computers on which to run the setup program.
$remoteComputers = 'computer1', 'computer2' # ...

# The full UNC path of the setup program.
$setupExePath = '\\server\somepath\setup.exe'

# Obtain credentials that can be used on the
# remote computers to access the share on which 
# the setup program is located.
$creds = Get-Credential

# Run the setup program on all remote computers.
Invoke-Command -ComputerName $remoteComputers {

    # WORKAROUND FOR THE DOUBLE-HOP PROBLEM:
    # Map the target network share as a dummy PS drive using the passed-through
    # credentials.
    # You may - but needn't - use this drive; the mere fact of having established
    # a drive with valid credentials makes the network location accessible in the
    # session, even with direct use of UNC paths.
    $null = New-PSDrive -Credential $using:cred dummy -Root (Split-Path -Parent $using:$setupExePath) -PSProvider FileSystem

    # Invoke the setup program from the UNC share.
    & $using:$setupExePath

    # ... do other things

}