you can use this simple trick
import SwiftUI
struct ContentView: View {
@State var selection = 0
let data = [1, 2, 3, 4, 5]
let disabled = [2, 3] // at index 2, 3
var body: some View {
let binding = Binding<Int>(get: {
self.selection
}) { (i) in
if self.disabled.contains(i) {} else {
self.selection = i
}
}
return VStack {
Picker(selection: binding, label: Text("label")) {
ForEach(0 ..< data.count) { (i) in
Text("\(self.data[i])")
}
}.pickerStyle(SegmentedPickerStyle())
Spacer()
}
}
}
struct ContentView_Previews: PreviewProvider {
static var previews: some View {
ContentView()
}
}

Maybe something like
ForEach(0 ..< data.count) { (i) in
if !self.disabled.contains(i) {
Text("\(self.data[i])")
} else {
Spacer()
}
}
could help to visualize it better

NOTES (based on the discussion)
From user perspective, the Picker is one control, which could be in disabled / enabled state.
The option selected from Picker is not control, it is some value. If you make a list of controls presented to the user, some of them could be disabled, just to inform the user, that the action associated with it is not currently available (like menu, some buttons collection etc.)
I suggest you to show in Picker only values which could be selected. This collection of values could be updated any time.
UPDATE
Do you like something like this?

No problem at all ... (copy - paste - try - modify ...)
import SwiftUI
struct Data: Identifiable {
let id: Int
let value: Int
var disabled: Bool
}
struct ContentView: View {
@State var selection = -1
@State var data = [Data(id: 0, value: 10, disabled: true), Data(id: 1, value: 20, disabled: true), Data(id: 2, value: 3, disabled: true), Data(id: 3, value: 4, disabled: true), Data(id: 4, value: 5, disabled: true)]
var filteredData: [Data] {
data.filter({ (item) -> Bool in
item.disabled == false
})
}
var body: some View {
VStack {
VStack(alignment: .leading, spacing: 0) {
Text("Select from avaialable")
.padding(.horizontal)
.padding(.top)
HStack {
GeometryReader { proxy in
Picker(selection: self.$selection, label: Text("label")) {
ForEach(self.filteredData) { (item) in
Text("\(item.value.description)").tag(item.id)
}
}
.pickerStyle(SegmentedPickerStyle())
.frame(width: CGFloat(self.filteredData.count) * proxy.size.width / CGFloat(self.data.count), alignment: .topLeading)
Spacer()
}.frame(height: 40)
}.padding()
}.background(Color.yellow.opacity(0.2)).cornerRadius(20)
Button(action: {
(0 ..< self.data.count).forEach { (i) in
self.data[i].disabled = false
}
}) {
Text("Enable all")
}
Button(action: {
self.data[self.selection].disabled = true
self.selection = -1
}) {
Text("Disable selected")
}.disabled(selection < 0)
Spacer()
}
}
}
struct ContentView_Previews: PreviewProvider {
static var previews: some View {
ContentView()
}
}
UISegmentedControl.