Keras: How to properly convert text to numeric array for input into sequential model: error 'XXX not in index'

Question

I have a data frame like this, of DNA sequences:

Feature         Label
GCTAGATGACAGT   0
TTTTAAAACAG     1
TAGCTATACT      2    
TGGGGCAAAAAAAA  0
AATGTCG         3
AATGTCG         0
AATGTCG         1

Where there is one column with a DNA sequence, and a label that can either be 0,1,2,3 (i.e. a category of that DNA sequence). I want to develop a NN that predicts probability of classification of each sequence into the 1,2 or 3 category (not 0, i don't care about 0). Each sequence can appear multiple times in the data frame, and it is possible that each sequence appears in multiple (or all) categories. So the output should look like this:

GCTAGATGACAGT   (0.9,0.1,0.2)
TTTTAAAACAG     (0.7,0.6,0.3)
TAGCTATACT      (0.3,0.3,0.2)    
TGGGGCAAAAAAAA  (0.1,0.5,0.6)

Where the numbers in the tuple are the probability that the sequence is found in category 1,2 and 3.

I'm having a basic problem of converting the text to numeric array for input into keras Sequential():

import numpy
from keras.datasets import imdb
from keras.models import Sequential
from keras.layers import Dense
from keras.layers import LSTM
from keras.layers import Dropout
from keras.layers.embeddings import Embedding
from keras.preprocessing import sequence
from sklearn.model_selection import StratifiedKFold
from keras.callbacks import EarlyStopping, ModelCheckpoint
import os
from random import random
from numpy import array
from numpy import cumsum
import pandas as pd
from keras.layers import TimeDistributed
from keras.layers import Bidirectional
from keras.preprocessing.text import Tokenizer
os.environ['KMP_DUPLICATE_LIB_OK']='True'
%matplotlib
from sklearn.feature_extraction.text import CountVectorizer


# fix random seed for reproducibility
seed = numpy.random.seed(7)
max_words = 10000

# load the data set into a data frame
df = pd.read_csv("test_dataset.csv")


# define 10-fold cross validation test harness
kfold = StratifiedKFold(n_splits=10, shuffle=True, random_state=seed)
X = df.iloc[:,[0]]
y = df.iloc[:,-1]
kf = kfold.get_n_splits(X)
cvscores = []


for train, test in kfold.split(X, y):

    X_train, X_test = X[train], X[test]
    y_train, y_test = y[train], y[test]

#    sequences = tokenizer.texts_to_sequences(X_train)
#    data = sequence.pad_sequences(sequences, maxlen= 100000) 


    tokenizer = Tokenizer(num_words=max_words)
    x_train = tokenizer.sequences_to_matrix(X_train, mode='binary')
    x_test = tokenizer.sequences_to_matrix(X_test, mode='binary')

#    y_train = keras.utils.to_categorical(y_train, num_classes)
#    y_test = keras.utils.to_categorical(y_test, num_classes)


The error: KeyError: '[    0     1     3 ... 62286 62287 62288] not in index'

You can see here I've tried a couple of ways (1) using tokenizer.sequences_to_matrix (and you get the error above) or (2) using texts_to_sequences (but you get the same error)

Can someone show me how I'm meant to be converting each sequence to an input suitable for keras (it's my first ever NN so an example would be great). Where I planned to go next with this is something like this (but this is untested as struggling to read sequences into the model at the minute):

  # create model
    model = Sequential()
#    model.add(Embedding(3000, 32, input_length=30))
#    model.add(Bidirectional(LSTM(20, return_sequences=True), input_shape=(n_timesteps, 1)))
    model.add(Dense(1, activation='sigmoid'))

    # Compile model
    model.compile(loss='binary_crossentropy', optimizer='adam', metrics=['accuracy'])

    # Monitor val accuracy and perform early stopping
#    es = EarlyStopping(monitor='val_loss', mode='min', verbose=1, patience=200)
#    mc = ModelCheckpoint('best_model.h5', monitor='val_accuracy', mode='max', verbose=1, save_best_only=True)

    # Fit the model
    model.fit(X_train, y_train, epochs=150, batch_size=10, verbose=0)


    # Evaluate the model
#    scores = model.evaluate(X[test], Y[test], verbose=0)
#    print("%s: %.2f%%" % (model.metrics_names[1], scores[1]*100))
#    cvscores.append(scores[1] * 100)
#print("%.2f%% (+/- %.2f%%)" % (numpy.mean(cvscores), numpy.std(cvscores)))

Update 1: I was wondering was I meant to convert sequences to matrix outside of the kfold loop like this:

# define 10-fold cross validation test harness
kfold = StratifiedKFold(n_splits=10, shuffle=True, random_state=seed)
X = df.iloc[:,[0]].values
y = df.iloc[:,-1].values
kf = kfold.get_n_splits(X)
cvscores = []

tokenizer = Tokenizer(num_words=1000000)
X = tokenizer.sequences_to_matrix(X, mode='binary')


for train, test in kfold.split(X, y):

    X_train, X_test = X[train], X[test]
    y_train, y_test = y[train], y[test]

    print(X_train[0:10])

But I get the error:

TypeError: '>=' not supported between instances of 'str' and 'int'

Edit 2: Tried an approach described here

kfold = StratifiedKFold(n_splits=10, shuffle=True, random_state=seed)
X = df.iloc[:,[0]].values
y = df.iloc[:,-1].values
kf = kfold.get_n_splits(X)
cvscores = []

le = LabelEncoder()
Y = le.fit_transform(y)
Y = Y.reshape(-1,1)


max_words = 1000
max_len = 150

for train, test in kfold.split(X, Y):

    X_train, X_test = X[train], X[test]
    y_train, y_test = y[train], y[test]

    tok = Tokenizer(num_words=max_words)
    tok.fit_on_texts(X_train)
    sequences = tok.texts_to_sequences(X_train)

With the error:

AttributeError: 'numpy.ndarray' object has no attribute 'lower'

Tinu · Accepted Answer · 2020-05-12 22:12:08Z

1

First of all a small code example how to use the Tokenizer class in your case:

data = ['GCTAGATGACAGT','TTTTAAAACAG','TAGCTATACT',
'TGGGGCAAAAAAAA','AATGTCG','AATGTCG','AATGTCG']
tokenizer = Tokenizer(num_words=5,char_level=True)
tokenizer.fit_on_texts(data)
data_encoded = tokenizer.texts_to_matrix(data,mode='count')
print(data_encoded)
print(tokenizer.word_index)

Output:

[[0., 4., 3., 4., 2.],
 [0., 5., 4., 1., 1.],
 [0., 3., 4., 1., 2.],
 [0., 8., 1., 4., 1.],
 [0., 2., 2., 2., 1.],
 [0., 2., 2., 2., 1.],
 [0., 2., 2., 2., 1.]]

 {'a': 1, 't': 2, 'g': 3, 'c': 4}

This should already solve the bigger part of your problem, I hope. Since you work with DNA sequences you should set num_words to a meaningful value. That is 5 in your case since you have A, C, G and T and the tokenizer class will use the most common num_words - 1 words (keras Tokenizer Documentation). Further you should use char_level=True because you operate on sequences of chars rather than on sentences. A number of other modes for encoding your sequences are available (tfidf, freq, binary).

Once you converted your sequences into vectors it should be straight forward to split the data into train/test sets and feed them to your model. I hope that solves your issues.

answered May 12, 2020 at 22:12

Tinu

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1 Comment

Slowat_Kela Over a year ago

perfect thanks so much, my first attempt at a model is running now!

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