Instead of using def inside the modify function, you can have a let with multiple bindings. Actually, def is typically only used at the top-level to define things once and is not meant to be a mechanism to allow for mutability. Here is an example of a let with multiple bindings, which is similar to introducing local variables except that you cannot change them:
(defn modify2 [my-list other params]
(if (nil? my-list)
my-list
(let [a (filter #(> (count %) 1) my-list)
b (adjust-values a)
c (adjust-values1 other b)
d (adjust-values2 params c)]
d)))
Here we introduce new names a, b, c and d for each partial result of the final computation. But it is OK to just have a single binding that gets rebound on each line, that is, you could have a single binding running that gets rebound:
(defn modify2 [my-list other params]
(if (nil? my-list)
my-list
(let [running (filter #(> (count %) 1) my-list)
running (adjust-values running)
running (adjust-values1 other running)
running (adjust-values2 params running)]
running)))
Which one you prefer is a matter of style and taste, there are up and downsides with either approach. The let form to introduce new bindings is a powerful construct, but for this specific example where we have a pipeline of steps, we can use the ->> macro that will generate the code for us. So we would instead write
(defn modify3 [my-list other params]
(if (nil? my-list)
my-list
(->> my-list
(filter #(> (count %) 1))
adjust-values
(adjust-values1 other)
(adjust-values2 params))))
It takes the first macro argument and then passes it in as the last parameter to the function call on the following line. Then the result of that line goes in as a last parameter to the line that follows and so on. If a function call just takes a single argument as is the case for adjust-values in the example above, we don't need to surround it with parentheses. See also the similar -> macro.
To see which code is generated by the ->>, we can use macroexpand:
(macroexpand '(->> my-list
(filter #(> (count %) 1))
adjust-values
(adjust-values1 other)
(adjust-values2 params)))
;; => (adjust-values2 params (adjust-values1 other (adjust-values (filter (fn* [p1__7109#] (> (count p1__7109#) 1)) my-list))))
Added: Summary
If your computation has a pipeline structure, the -> and ->> macros can be used to express that computation concisely. However, if your computation has a general shape where, you will want to use let to associate symbols with results of sub-expressions, so that you can use those symbols in subsequent expressions inside the let form.