Quoting Python documentation on boolean operations,
In the context of Boolean operations, and also when expressions are used by control flow statements, the following values are interpreted as false: False, None, numeric zero of all types, and empty strings and containers (including strings, tuples, lists, dictionaries, sets and frozensets). All other values are interpreted as true.
So, if my_variable will fail, if my_variable has any of the above mentioned falsy values where as the second one will fail only if my_variable is None. Normally the variables are initialized with None as a placeholder value and if it is not None at some point of time in the program then they will know that some other value has been assigned to it.
For example,
def print_name(name=None):
if name is not None:
print(name)
else:
print("Default name")
Here, the function print_name expects one argument. If the user provides it, then it may not be None, so we are printing the actual name passed by the user and if we don't pass anything, by default None will be assigned. Now, we check if name is not None to make sure that we are printing the actual name instead of the Default name.
Note: If you really want to know if your variable is defined or not, you might want to try this
try:
undefined_variable
except NameError as e:
# Do whatever you want if the variable is not defined yet in the program.
print(e)