How to use hex() without 0x in Python?

Use this code:

'{:x}'.format(int(line))

it allows you to specify a number of digits too:

'{:06x}'.format(123)
# '00007b'

For Python 2.6 use

'{0:x}'.format(int(line))

or

'{0:06x}'.format(int(line))

You can simply write

hex(x)[2:]

to get the first two characters removed.

Python 3.6+:

>>> i = 240
>>> f'{i:x}'  # 02x to pad with zeros
'f0'

Old style string formatting:

In [3]: "%x" % 127
Out[3]: '7f'

New style

In [7]: '{:x}'.format(127)
Out[7]: '7f'

Using capital letters as format characters yields uppercase hexadecimal

In [8]: '{:X}'.format(127)
Out[8]: '7F'

Docs are here.

'x' - Outputs the number in base 16, using lower-case letters for the digits above 9.

>>> format(3735928559, 'x')
'deadbeef'

'X' - Outputs the number in base 16, using upper-case letters for the digits above 9.

>>> format(3735928559, 'X')
'DEADBEEF'

You can find more information about that in Python's documentation:

• Format Specification Mini-Language
• format()

F-strings

Python 3's formatted literal strings (f-strings) support the Format Specification Mini-Language, which designates x for hexadecimal numbers. The output doesn't include 0x.

So you can do this:

>>> f"{3735928559:x}"
'deadbeef'

See the spec for other bases like binary, octal, etc.

Edit: str.removeprefix

Since Python 3.9, there is now a str.removeprefix method, which allows you to write the following more obvious code:

>>> hexadecimal = hex(3735928559)
>>> hexadecimal.removeprefix('0x')
'deadbeef'

Not that this does NOT work for negative numbers ❌:

>>> negadecimal = hex(-3735928559)
>>> negadecimal.removeprefix('0x')
'-0xdeadbeef'

Besides going through string formatting, it is interesting to have in mind that when working with numbers and their hexadecimal representation we usually are dealing with byte-content, and interested in how bytes relate.

The bytes class in Python 3 had been enriched with methods over the 3.x series, and int.to_bytes combined with the bytes.hex() provide full control of the hex-digits output, while preserving the semantics of the transform (not to mention, holding the intermediate "bytes" object ready to be used in any binary protocol that requires the number):

In [8]: i = 3735928559

In [9]: i.to_bytes(4, "big").hex()
Out[9]: 'deadbeef'

Besides that, bytes.hex() allow some control over the output, such as specifying a separator for the hex digits:

In [10]: bytes.hex?
Docstring:
Create a string of hexadecimal numbers from a bytes object.

  sep
    An optional single character or byte to separate hex bytes.
  bytes_per_sep
    How many bytes between separators.  Positive values count from the
    right, negative values count from the left.

Example:
>>> value = b'\xb9\x01\xef'
>>> value.hex()
'b901ef'
>>> value.hex(':')
'b9:01:ef'
>>> value.hex(':', 2)
'b9:01ef'
>>> value.hex(':', -2)
'b901:ef'

(That said, in most scenarios just a quick print is wanted, I'd probably just go through f-string formatting, as in the accepted answer: f"{mynumber:04x}" - for the simple reason of "less things to remember")

While all of the previous answers will work, a lot of them have caveats like not being able to handle both positive and negative numbers or only work in Python 2 or 3. The version below works in both Python 2 and 3 and for positive and negative numbers:

Since Python returns a string hexadecimal value from hex() we can use string.replace to remove the 0x characters regardless of their position in the string (which is important since this differs for positive and negative numbers).

hexValue = hexValue.replace('0x','')

EDIT: wjandrea made a good point in that the above implementation doesn't handle values that contain 0X instead of 0x, which can occur in int literals. With this use case in mind, you can use the following case-insensitive implementation for Python 2 and 3:

import re
hexValue = re.sub('0x', '', hexValue, flags=re.IGNORECASE)