I am trying to design a layout that looks something like this:

I want the entire layout to be designed using percentages instead of px. I think I am fairly close, but I am having issues with the margins or something. Here is my current code:
CSS
html, body {
width: 95%;
margin: 0 auto;
height: 100%;
}
#header {
margin: 0;
background-color: #000000;
height: 5%;
width: 100%;
}
#wrapper {
height: 95%;
margin: 0;
}
#content {
width: 100%;
overflow: hidden;
height: 95%;
margin: 0;
}
#left {
margin: 0;
width: 25%;
height: 500px;
float: left;
}
#right {
float: left;
width: 75%;
height: 100%;
margin-right: 0%;
display: inline;
}
.boxes {
margin: .5%;
width: 48%;
height: 48%;
}
#topleft {
float: left;
}
#topright {
float: left;
display: inline;
}
#bottomleft {
float: left;
}
#bottomright {
float: left;
display: inline;
}
HTML
<html>
<body>
<div id="header">
</div>
<div id="wrapper">
<div id="content">
<div id="left">
</div>
<div id="right">
<div class="boxes" id="topleft"></div>
<div class="boxes" id="topright"></div>
<div class="boxes" id="bottomleft"></div>
<div class="boxes" id="bottomright"></div>
</div>
</div>
</div>
</body>
</html>
What else do I need to add to my CSS and or HTML code to get the layout I am looking for? Any help would be greatly appreciated.